Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJUXKY)

Drug Name

GTPgammaS Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Chloride channel protein 7 (ClC-7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NPPB	DMFIWAN	Discovery agent	N.A.	Investigative	[4]
DIDS	DMKSQUB	Discovery agent	N.A.	Investigative	[4]
diphenylamine-2-carboxylic acid	DMBV19T	Discovery agent	N.A.	Investigative	[2]
SITS	DMCMIUG	Discovery agent	N.A.	Investigative	[2]
NS5818	DM629TD	Discovery agent	N.A.	Investigative	[4]
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Drug(s) Targeting Volume regulated chloride channel (VRAC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NPPB	DMFIWAN	Discovery agent	N.A.	Investigative	[3]
DIDS	DMKSQUB	Discovery agent	N.A.	Investigative	[3]
9-anthroic acid	DMGCVT2	Discovery agent	N.A.	Investigative	[3]
1,9-dideoxyforskolin	DMW613U	Discovery agent	N.A.	Investigative	[3]
diBA-(5)-C4	DM9KPHZ	Discovery agent	N.A.	Investigative	[3]
IAA-94	DMFSAK3	Discovery agent	N.A.	Investigative	[3]
DCPIB	DM9NMIY	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Chloride channel protein 7 (ClC-7)	TTST1AJ	CLCN7_HUMAN	Activator	[2]
Volume regulated chloride channel (VRAC)	TT0FC1V	NOUNIPROTAC	Activator	[3]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4207).
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 709).
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 710).
4	The G215R mutation in the Cl-/H+-antiporter ClC-7 found in ADO II osteopetrosis does not abolish function but causes a severe trafficking defect. PLoS One. 2010 Sep 7;5(9):e12585.