Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMK17GN)

Drug Name

KM-4056 Drug Info

Synonyms

Anti-LGR5 monoclonal antibody (cancer), Kyowa Hakko Kirin

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Preclinical Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Leucine-rich repeat-containing GPCR 5 (LGR5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MCLA-158	DMF0O3X	Solid tumour/cancer	2A00-2F9Z	Phase 1	[2]
BNC-101	DMSBM6A	Metastatic colorectal cancer	2B91	Phase 1	[3]
BNC-102	DMM1O0P	Solid tumour/cancer	2A00-2F9Z	Preclinical	[4]
------------------------------------------------------------------------------------

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Leucine-rich repeat-containing GPCR 5 (LGR5)	TTTSGRH	LGR5_HUMAN	Not Available	[1]

------------------------------------------------------------------------------------

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 148).
2	Clinical pipeline report, company report or official report of Merus.
3	Clinical pipeline report, company report or official report of Bionomics.
4	Opportunities for therapeutic antibodies directed at G-protein-coupled receptors. Nat Rev Drug Discov. 2017 Sep 1;16(9):661.