Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMK8LEC)

Drug Name

OF-1 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Bromodomain-containing protein 1 (BRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NI-57	DM52ITO	Discovery agent	N.A.	Investigative	[3]
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Drug(s) Targeting Bromodomain and PHD finger containing 1 (BRPF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NI-57	DM52ITO	Discovery agent	N.A.	Investigative	[2]
PMID25408830C3	DM8SBR2	Discovery agent	N.A.	Investigative	[4]
PMID25408830C1	DM5GL23	Discovery agent	N.A.	Investigative	[4]
PMID25974391C34	DMGWZA3	Discovery agent	N.A.	Investigative	[5]
PMID25408830C2	DM20E13	Discovery agent	N.A.	Investigative	[4]
PFI-4	DMPKXNZ	Discovery agent	N.A.	Investigative	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bromodomain and PHD finger containing 1 (BRPF1)	TTT46BN	BRPF1_HUMAN	Inhibitor	[2]
Bromodomain-containing protein 1 (BRD1)	TTT09OB	BRD1_HUMAN	Inhibitor	[3]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8574).
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2730).
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2724).
4	1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain. ACS Med Chem Lett. 2014 Sep 10;5(11):1190-5.
5	Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF. J Med Chem. 2016 Feb 25;59(4):1642-7.