Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMK8XIO)

Drug Name

6-Benzyloxy-5-nitro-pyrimidine-2,4-diamine Drug Info

Synonyms

CHEMBL121479; 127116-64-7; 2,4-Pyrimidinediamine, 5-nitro-6-(phenylmethoxy)-; ACMC-20msby; 6-Benzyloxy-5-nitro-pyrimidine-2,4-diamine; SCHEMBL3309544; CTK0F6457; DTXSID40431990; VLVHHGNPHBVEIG-UHFFFAOYSA-N; BDBM50062813; AKOS030620964; 6-Benzyloxy-5-nitropyrimidine-2,4-diamine; 2,4-Diamino-6-benzyloxy-5-nitropyrimidine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 9860003
CAS Number: CAS 127116-64-7
TTD Drug ID: DMK8XIO

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting O-6-methylguanine-DNA-alkyltransferase (MGMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
O6-Benzylguanine alkylade	DM3L2GT	Sarcoma	2A60-2C35	Phase 3	[2]
6-Benzyloxy-9H-purin-2-ylamine	DMFI7A8	Discovery agent	N.A.	Investigative	[1]
S-Methylcysteine	DMAMRKS	Discovery agent	N.A.	Investigative	[3]
6-Benzyloxy-5-nitroso-pyrimidine-2,4-diamine	DMUFSE2	Discovery agent	N.A.	Investigative	[1]
Benzylcysteine	DMTCYHM	Discovery agent	N.A.	Investigative	[3]
6-Allyloxy-9H-purin-2-ylamine	DMI2XUQ	Discovery agent	N.A.	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
O-6-methylguanine-DNA-alkyltransferase (MGMT)	TTJ8DV7	MGMT_HUMAN	Inhibitor	[1]

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References

1	Inhibition of human O6-alkylguanine-DNA alkyltransferase and potentiation of the cytotoxicity of chloroethylnitrosourea by 4(6)-(benzyloxy)-2,6(4)-... J Med Chem. 1998 Feb 12;41(4):503-8.
2	Phase II trial of temozolomide plus o6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma. J Clin Oncol. 2009 Mar 10;27(8):1262-7.
3	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
4	Resistance-modifying agents. 8. Inhibition of O(6)-alkylguanine-DNA alkyltransferase by O(6)-alkenyl-, O(6)-cycloalkenyl-, and O(6)-(2-oxoalkyl)gua... J Med Chem. 2000 Nov 2;43(22):4071-83.