Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKAIR9)

Drug Name

AZD9574 Drug Info

Synonyms

AZD-9574; AZD9574; 2756333-39-6; 9UG32UQW48; UNII-9UG32UQW48; 2-Pyridinecarboxamide, 6-fluoro-5-(4-((5-fluoro-3,4-dihydro-2-methyl-3-oxo-6-quinoxalinyl)methyl)-1-piperazinyl)-N-methyl-; 6-fluoro-5-[4-[(5-fluoro-2-methyl-3-oxo-4H-quinoxalin-6-yl)methyl]piperazin-1-yl]-N-methylpyridine-2-carboxamide; 6-fluoro-5-{4-[(5-fluoro-2-methyl-3-oxo-4H-quinoxalin-6-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide; CHEMBL5095223; SCHEMBL24156588; GTPL11946; GLXC-25685; EX-A6177; NSC840950; AKOS040759967; AT34947; NSC-840950; example 20 [WO2021260092A1]; MS-27579; HY-145804; CS-0433406; 6-FLUORO-5-(4-((5-FLUORO-2-METHYL-3-OXO-3,4-DIHYDROQUINOXALIN-6-YL)METHYL)PIPERAZIN-1-YL)-N-METHYLPICOLINAMIDE

Indication

Disease Entry	ICD 11	Status	REF
Aggressive cancer	2A00-2F9Z	Phase 2	[1]

Cross-matching ID

PubChem CID: 162524593
TTD Drug ID: DMKAIR9

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Poly [ADP-ribose] polymerase (PARP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Olaparib	DM8QB1D	Ovarian cancer	2C73	Approved	[3]
Rucaparib	DM9PVX8	Ovarian cancer	2C73	Approved	[4]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[5]
MK-4827	DMLYGH4	Ovarian cancer	2C73	Phase 3	[6]
BSI-201	DMM0VO3	Solid tumour/cancer	2A00-2F9Z	Phase 3	[7]
Rubraca rucaparib	DM25TMP	Ovarian cancer	2C73	Phase 3	[8]
ABT-888	DM4HYMS	Breast cancer	2C60-2C65	Phase 3	[6]
INO-1001	DM5L8QT	Brain cancer	2A00	Phase 3	[9]
BGP-15	DMYDM68	Type-2 diabetes	5A11	Phase 2	[10]
BGB-290	DMRO6XT	Ovarian cancer	2C73	Phase 2	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Poly [ADP-ribose] polymerase (PARP)	TTEBCY8	NOUNIPROTAC	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT05417594) A Modular Phase I/IIa, Open-label, Multi-centre Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of Ascending Doses of AZD9574 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies (CERTIS1). U.S.National Institutes of Health.
2	Clinical pipeline report, company report or official report of AstraZeneca
3	2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
4	2016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76.
5	2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
6	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
7	Failure of iniparib to inhibit poly(ADP-Ribose) polymerase in vitro. Clin Cancer Res. 2012 Mar 15;18(6):1655-62.
8	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
9	Therapeutic injection of PARP inhibitor INO-1001 preserves cardiac function in porcine myocardial ischemia and reperfusion without reducing infarct size. Shock. 2010 May;33(5):507-12.
10	BGP-15, a PARP-inhibitor, prevents imatinib-induced cardiotoxicity by activating Akt and suppressing JNK and p38 MAP kinases. Mol Cell Biochem. 2012 Jun;365(1-2):129-37.