Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKFMYR)

Drug Name

CLOTURIN Drug Info

Synonyms

VUFB-15686; N-(2-Chloroethyl)thiocarbamic acid 6-purinyl ester; (2-Chloroethyl)carbamothioic acid S-1H-purin-6-yl ester; 6-[N-(2-Chloroethyl)carbamoyl]thiopurine

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 2	[1]

Cross-matching ID

PubChem CID: 128676
CAS Number: CAS 104789-46-0
TTD Drug ID: DMKFMYR

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting DNA synthesis (DNA synth)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nelarabine	DMB6VEG	leukaemia	2A60-2B33	Approved	[3]
Glufosfamide	DMEFCTP	Pancreatic cancer	2C10	Phase 3	[4]
acelarin	DMY96O3	Biliary tract cancer	2C17	Phase 3	[4]
FF-10502-01	DMX5290	Lymphoma	2A80-2A86	Phase 1	[4]
TAR-200	DMSQZEP	Bladder cancer	2C94	Phase 1	[4]
EPD-clofarabine	DM149HL	Solid tumour/cancer	2A00-2F9Z	Terminated	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
DNA synthesis (DNA synth)	TTUBNVO	NOUNIPROTAC	Modulator	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002443)
2	Inhibition of biosynthetic processes in P388 and Ehrlich ascites cells by cloturin. Drugs Exp Clin Res. 1988;14(9):575-80.
3	Nelarabine. Drugs. 2008;68(4):439-47.
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5	2004 approvals: the demise of the blockbuster. Nat Rev Drug Discov. 2005 Feb;4(2):93-4.