Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKGXB9)

Drug Name

Thymine Drug Info

Synonyms

5-methyluracil; 65-71-4; 2,4-Dihydroxy-5-methylpyrimidine; Thymin; 5-methylpyrimidine-2,4(1H,3H)-dione; Thymine anhydrate; 2,4(1H,3H)-Pyrimidinedione, 5-methyl-; 5-methyl-2,4(1H,3H)-pyrimidinedione; Thymin (purine base); 5-Methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione; 5-methyl-1H-pyrimidine-2,4-dione; CCRIS 5584; UNII-QR26YLT7LT; 5-Methyl Uracil; 5-Methylpyrimidine-2,4-dione; 4-Hydroxy-5-methylpyrimidin-2(1H)-one; CHEBI:17821; AI3-25479; NSC14705; EINECS 200-616-1; NSC 14705; QR26YLT7LT; CHEMBL993

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 1135
ChEBI ID: CHEBI:17821
CAS Number: CAS 65-71-4
TTD Drug ID: DMKGXB9

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Thymidine phosphorylase (TYMP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Uridine	DMQTREB	Depression	6A70-6A7Z	Approved	[4]
5-bromo-6-hydrazinouracil hydrochloride	DMZJE6M	Discovery agent	N.A.	Investigative	[5]
5-fluoro-6-[(2-aminoimidazol-1-yl)methyl]uracil	DMEV0GO	Discovery agent	N.A.	Investigative	[6]
6-chloro-5-phenylpyrimidine-2,4(1H,3H)-dione	DM90JMN	Discovery agent	N.A.	Investigative	[7]
6-chloro-5-heptylpyrimidine-2,4(1H,3H)-dione	DMASFR6	Discovery agent	N.A.	Investigative	[7]
1-(cyclohexyl)methyl-5'-O-tritylinosine	DMS3XUC	Discovery agent	N.A.	Investigative	[8]
1-(cyclopropyl)methyl-5'-O-tritylinosine	DMDU3X7	Discovery agent	N.A.	Investigative	[8]
1-propyl-5'-O-tritylinosine	DM5P01L	Discovery agent	N.A.	Investigative	[8]
1-allyl-5'-O-tritylinosine	DM2J5WH	Discovery agent	N.A.	Investigative	[8]
5-benzyl-6-chloropyrimidine-2,4(1H,3H)-dione	DMCKODQ	Discovery agent	N.A.	Investigative	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Thymidine phosphorylase (TYMP)	TTO0IB8	TYPH_HUMAN	Inhibitor	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Thymidine phosphorylase	OT6BQTMR	TYPH_HUMAN	Regulation of Drug Effects	[3]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4581).
2	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
3	Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors. Cancer Res. 2000 Nov 15;60(22):6298-302.
4	Enzymatic activities of uridine and thymidine phosphorylase in normal and cancerous uterine cervical tissues. Hum Cell. 2007 Nov;20(4):107-10.
5	Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1335-7.
6	The role of phosphate in the action of thymidine phosphorylase inhibitors: Implications for the catalytic mechanism. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1648-51.
7	Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase. J Med Chem. 2007 Nov 29;50(24):6016-23.
8	5'-O-tritylinosine and analogues as allosteric inhibitors of human thymidine phosphorylase. J Med Chem. 2006 Sep 7;49(18):5562-70.