Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKGXB9)

Drug Name
Thymine Drug Info
Synonyms
5-methyluracil; 65-71-4; 2,4-Dihydroxy-5-methylpyrimidine; Thymin; 5-methylpyrimidine-2,4(1H,3H)-dione; Thymine anhydrate; 2,4(1H,3H)-Pyrimidinedione, 5-methyl-; 5-methyl-2,4(1H,3H)-pyrimidinedione; Thymin (purine base); 5-Methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione; 5-methyl-1H-pyrimidine-2,4-dione; CCRIS 5584; UNII-QR26YLT7LT; 5-Methyl Uracil; 5-Methylpyrimidine-2,4-dione; 4-Hydroxy-5-methylpyrimidin-2(1H)-one; CHEBI:17821; AI3-25479; NSC14705; EINECS 200-616-1; NSC 14705; QR26YLT7LT; CHEMBL993
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
1135
ChEBI ID
CHEBI:17821
CAS Number
CAS 65-71-4
TTD Drug ID
DMKGXB9

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Thymidine phosphorylase (TYMP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Uridine DMQTREB Depression 6A70-6A7Z Approved [3]
5-bromo-6-hydrazinouracil hydrochloride DMZJE6M Discovery agent N.A. Investigative [4]
5-fluoro-6-[(2-aminoimidazol-1-yl)methyl]uracil DMEV0GO Discovery agent N.A. Investigative [5]
6-chloro-5-phenylpyrimidine-2,4(1H,3H)-dione DM90JMN Discovery agent N.A. Investigative [6]
6-chloro-5-heptylpyrimidine-2,4(1H,3H)-dione DMASFR6 Discovery agent N.A. Investigative [6]
1-(cyclohexyl)methyl-5'-O-tritylinosine DMS3XUC Discovery agent N.A. Investigative [7]
1-(cyclopropyl)methyl-5'-O-tritylinosine DMDU3X7 Discovery agent N.A. Investigative [7]
1-propyl-5'-O-tritylinosine DM5P01L Discovery agent N.A. Investigative [7]
1-allyl-5'-O-tritylinosine DM2J5WH Discovery agent N.A. Investigative [7]
5-benzyl-6-chloropyrimidine-2,4(1H,3H)-dione DMCKODQ Discovery agent N.A. Investigative [6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Thymidine phosphorylase (TYMP) TTO0IB8 TYPH_HUMAN Inhibitor [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4581).
2 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
3 Enzymatic activities of uridine and thymidine phosphorylase in normal and cancerous uterine cervical tissues. Hum Cell. 2007 Nov;20(4):107-10.
4 Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1335-7.
5 The role of phosphate in the action of thymidine phosphorylase inhibitors: Implications for the catalytic mechanism. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1648-51.
6 Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase. J Med Chem. 2007 Nov 29;50(24):6016-23.
7 5'-O-tritylinosine and analogues as allosteric inhibitors of human thymidine phosphorylase. J Med Chem. 2006 Sep 7;49(18):5562-70.