Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKP8L9)

Drug Name

AMG-889436 Drug Info

Synonyms

Metabotropic glutamate receptor 4 agonist (Parkinson's disease), Amgen; Metabotropic glutamate receptor 4 positive allosteric modulator (Parkinson's disease), Amgen

Indication

Disease Entry	ICD 11	Status	REF
Parkinson disease	8A00.0	Investigative	[1]

Cross-matching ID

TTD Drug ID: DMKP8L9

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Glutamate receptor AMPA 4 (GRIA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
E-2007	DMJDYNQ	Diabetic neuropathy	8C0Z	Approved	[2]
[3H]CNQX	DMIFKUX	Discovery agent	N.A.	Investigative	[1]
ATPO	DMXLS78	Discovery agent	N.A.	Investigative	[1]
(S)-5-fluorowillardiine	DMCIZ7P	Discovery agent	N.A.	Investigative	[1]
[3H]AMPA	DMLF7SG	N. A.	N. A.	Investigative	[1]
joro toxin	DMYBJ4K	Discovery agent	N.A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutamate receptor AMPA 4 (GRIA4)	TTPJR0G	GRIA4_HUMAN	Agonist	[1]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 447).
2	Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.