Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKS4Z9)

Drug Name

IL1aQb Drug Info

Synonyms

IL1aQb therapeutic vaccines (atherosclerosis); CYT-018-IL1aQb; IL1aQb therapeuticvaccines (atherosclerosis), Cytos; Immunodrug vaccines (atherosclerosis), Cytos

Indication

Disease Entry	ICD 11	Status	REF
Arteriosclerosis	BD40	Terminated	[1]

Cross-matching ID

TTD Drug ID: DMKS4Z9

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Interleukin-1 alpha (IL1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MABp1	DM8D13S	Colorectal cancer	2B91.Z	Phase 3	[3]
Xilonix	DMK34MZ	Colorectal cancer	2B91.Z	Phase 3	[4]
ABT-981	DM6PTIX	Osteoarthritis	FA00-FA05	Phase 2	[5]
Bermekimab	DM7A592	Hidradenitis suppurativa	ED92.0	Phase 2	[6]
Natrunix	DMBRSWJ	Arthritis	FA20	Phase 2	[7]
IX207-887	DM4TE8R	Rheumatoid arthritis	FA20	Discontinued in Phase 2	[8]
Interleukin-1-alpha - Amgen/Roche	DMB9AIX	Discovery agent	N.A.	Investigative	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interleukin-1 alpha (IL1A)	TTPM6HI	IL1A_HUMAN	Not Available	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021743)
2	Cytos Biotechnology AG - Product Pipeline Review - 2013. Global Markets Direct. Dec 2013.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Clinical pipeline report, company report or official report of xbiotech.
5	Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1alpha and IL-1beta. MAbs. 2015;7(3):605-19.
6	Target molecules for future hidradenitis suppurativa treatment. Exp Dermatol. 2021 Jun;30 Suppl 1:8-17.
7	ClinicalTrials.gov (NCT05363917) Phase II Double-Blinded, Placebo-Controlled Randomized Study Examining the Safety and Efficacy of Natrunix Versus Methotrexate (+Folate) for the Treatment of Rheumatoid Arthritis. U.S.National Institutes of Health.
8	Inhibition of interleukin-1 release by IX 207-887. Agents Actions. 1990 Jun;30(3-4):350-62.
9	Identification of regions in interleukin-1 alpha important for activity. J Biol Chem. 1993 Oct 15;268(29):22105-11.