Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKSUV9)

Drug Name

3-tapap Drug Info

Synonyms

3-Tapap; TAPAP; AC1Q5K4B; AC1L2Q7B; Nalpha-Tosyl-(3-amidinophenyl)alanine piperidide; N(alpha)-(4-Toluenesulfonyl)-3-amidinophenylalanylpiperidine; CHEMBL384295; 80457-09-6; 3-[2-{[(4-methylphenyl)sulfonyl]amino}-3-oxo-3-(piperidin-1-yl)propyl]benzenecarboximidamide; 1-(3-(3-(Aminoiminomethyl)phenyl)-2-(((4-methylphenyl)sulfonyl)amino)-1-oxopropyl)piperidine; Piperidine, 1-(3-(3-(aminoiminomethyl)phenyl)-2-(((4-methylphenyl)sulfonyl)amino)-1-oxopropyl)-; 73438-63-8; N(alpha)-Tosyl-(3-amidinophenyl)alanine piperidide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 126363
CAS Number: CAS 73438-63-8
TTD Drug ID: DMKSUV9

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Suppressor of tumorigenicity 14 protein (ST14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US8569313, Inhibitor 18	DMXTCGM	N. A.	N. A.	Patented	[2]
US8569313, Inhibitor 14	DMZV6YT	N. A.	N. A.	Patented	[2]
US8569313, Inhibitor 19	DMLXG43	N. A.	N. A.	Patented	[2]
US8569313, Inhibitor 15	DMTMG02	N. A.	N. A.	Patented	[2]
PMID23849879C3	DMUW3MT	Discovery agent	N.A.	Investigative	[3]
PMID25489658C4d	DMWZJT0	Discovery agent	N.A.	Investigative	[4]
Benzamidine	DM37GWL	Discovery agent	N.A.	Investigative	[5]
2-nas-phe(3-am)-4-(2-guanidinoethyl)piperidine	DMFXKN1	Discovery agent	N.A.	Investigative	[1]
Inhibitor 1 [Colombo et al., 2012]	DMUQHMP	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Suppressor of tumorigenicity 14 protein (ST14)	TTPRO7W	ST14_HUMAN	Inhibitor	[1]

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References

1	Secondary amides of sulfonylated 3-amidinophenylalanine. New potent and selective inhibitors of matriptase. J Med Chem. 2006 Jul 13;49(14):4116-26.
2	Meta-substituted phenyl sulfonyl amides of secondary amino acid amides, the production thereof, and use thereof as matriptase inhibitors. US8569313.
3	1,2,4-Triazole derivatives as transient inactivators of kallikreins involved in skin diseases. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4547-51.
4	Toward the first class of suicide inhibitors of kallikreins involved in skin diseases. J Med Chem. 2015 Jan 22;58(2):598-612.
5	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
6	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2418).