Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKWTPX)

Drug Name

FLM-5011 Drug Info

Synonyms

1-(2-Hydroxy-5-methylphenyl)-1-dodecanone oxime; 2-Hydroxy-5-methylaurophenone oxime

Indication

Disease Entry	ICD 11	Status	REF
Inflammation	1A00-CA43.1	Discontinued in Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Lipoxygenase (ALOX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TZI-41078	DMKJIDU	Arthritis	FA20	Phase 2	[3]
CPA-926	DMH5LKS	Arthritis	FA20	Discontinued in Phase 2	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002782)
2	Lipoxygenase inhibitor FLM 5011, an effective protectant of myocardial microvessels against ischemia-reperfusion injury. Exp Toxicol Pathol. 2000 Mar;52(1):27-36.
3	Hydroxylamine analogs of 2,6-di-t-butylphenols: dual inhibitors of cyclooxygenase and 5-lipoxygenase or selective 5-lipoxygenase inhibitors. Bioorg Med Chem. 1995 Apr;3(4):403-10.
4	Esculetin (dihydroxycoumarin) inhibits the production of matrix metalloproteinases in cartilage explants, and oral administration of its prodrug, CPA-926, suppresses cartilage destruction in rabbit experimental osteoarthritis. J Rheumatol. 1999 Mar;26(3):654-62.