Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DML20N9)

Drug Name

A-80040 Drug Info

Synonyms

CHEMBL378186; A-80040; SCHEMBL16705052; BDBM50189633

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Acetyl-CoA carboxylase 2 (ACACB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metformin	DM89QE1	Colorectal carcinoma		Approved	[2]
PF-05175157	DMLQ3OK	Type-2 diabetes	5A11	Phase 2	[3]
Axokine	DMT5O8I	Obesity	5B81	Discontinued in Phase 3	[4]
CP-640186	DMO0PS9	Discovery agent	N.A.	Investigative	[5]
AC-8632	DM09BJ4	Parkinson disease	8A00.0	Investigative	[3]
QLT-091382	DMWOSFJ	Sebaceous gland disease	EM0Z	Investigative	[3]
2-[4-(2,4-Dichlorophenoxy)Phenoxy]Propanoic Acid	DMWXI06	Discovery agent	N.A.	Investigative	[6]
Soraphen A	DM18IKZ	Discovery agent	N.A.	Investigative	[7]
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⏷ Show the Full List of 8 Drug(s)

Drug(s) Targeting Plasmodium Acetyl-CoA carboxylase 1 (Malaria ACC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CP-640186	DMO0PS9	Discovery agent	N.A.	Investigative	[8]
AC-8632	DM09BJ4	Parkinson disease	8A00.0	Investigative	[9]
Haloxyfop	DM5SULN	Discovery agent	N.A.	Investigative	[10]
Clodinafop	DMALRU9	Discovery agent	N.A.	Investigative	[10]
Quizalofop	DM9KMEI	Discovery agent	N.A.	Investigative	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Acetyl-CoA carboxylase 2 (ACACB)	TTY84UG	ACACB_HUMAN	Inhibitor	[1]
Plasmodium Acetyl-CoA carboxylase 1 (Malaria ACC1)	TTYAWV0	Q9U752_PLAFA	Inhibitor	[1]

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References

1	Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acet... J Med Chem. 2006 Jun 29;49(13):3770-3.
2	AMP-activated protein kinase-dependent and -independent mechanisms underlying in vitro antiglioma action of compound C. Biochem Pharmacol. 2009 Jun 1;77(11):1684-93.
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1264).
4	Obesity: pathophysiology and clinical management. Curr Med Chem. 2009;16(4):506-21.
5	(4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6645-8.
6	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
7	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
8	Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2383-8.
9	Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science. 2000 Jun 30;288(5475):2379-81.
10	The apicoplast as an antimalarial drug target. Drug Resist Updat. 2001 Jun;4(3):145-51.