Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DML2VSZ)

Drug Name

H3B-8800 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Myelodysplastic syndrome	2A37	Phase 2	[1]
Acute myeloid leukaemia	2A60	Phase 1	[2]
Chronic myelogenous leukaemia	2A20.0	Phase 1	[2]
Chronic myelomonocytic leukaemia	2A40	Phase 1	[3]

Cross-matching ID

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
SF3b complex (SF3b)	TTXR78S	SF3B1_HUMAN-SF3B2_HUMAN-SF3B3_HUMAN-SF3B4_HUMAN-SF3B5_HUMAN-SF3B6_HUMAN	Modulator	[4]

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References

1	Targeting mRNA processing as an anticancer strategy. Nat Rev Drug Discov. 2020 Feb;19(2):112-129.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	ClinicalTrials.gov (NCT02841540) A Study of H3B-8800 in Participants With Myelodysplastic Syndromes, Acute Myeloid Leukemia, and Chronic Myelomonocytic Leukemia. U.S. National Institutes of Health.
4	Clinical pipeline report, company report or official report of H3 Biomedicine.