General Information of Drug (ID: DML4H05)

Drug Name
KX2-361 Drug Info
Synonyms KX-02
Indication
Disease Entry ICD 11 Status REF
Brain cancer 2A00 Phase 1 [1]
Glioblastoma multiforme 2A00.0 Phase 1 [2]
Cross-matching ID
PubChem CID
11545920
CAS Number
CAS 897016-26-1
TTD Drug ID
DML4H05

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug(s) Targeting Proto-oncogene c-Src (SRC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dasatinib DMJV2EK Chronic myelogenous leukaemia 2A20.0 Approved [4]
Bosutinib DMTI8YE Breast cancer 2C60-2C65 Approved [4]
SKI-758 DMQ8E9R Ischemia 8B10-8B11 Approved [5]
Herbimycin A DM6YWBF Solid tumour/cancer 2A00-2F9Z Approved [6]
Al3818 DM3WP0N Alveolar soft part sarcoma 2A60-2C35 Phase 3 [7]
CP-868596 DMZIM37 Gastrointestinal cancer 2C11 Phase 3 [7]
Masitinib DMRSNEU Amyotrophic lateral sclerosis 8B60.0 Phase 3 [8]
KX-01 DMF0NA9 Actinic keratosis EK90.0 Phase 3 [9]
Saracatinib DMBLHGP Hematologic tumour 2B33.Y Phase 2 [10]
TPX-0046 DMIVE67 Solid tumour/cancer 2A00-2F9Z Phase 1/2 [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Proto-oncogene c-Src (SRC) TT6PKBN SRC_HUMAN Inhibitor [3]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800041844)
2 ClinicalTrials.gov (NCT02326441) Safety, Tolerability & PK of KX2-361 in Subjects w Adv. Malignancies Refractory to Conventional Therapies. U.S. National Institutes of Health.
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2206).
4 A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.
5 Synthesis and Src kinase inhibitory activity of a series of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-furyl-3-quinolinecarbonitriles. J Med Chem. 2006 Dec 28;49(26):7868-76.
6 In vivo antitumor activity of herbimycin A, a tyrosine kinase inhibitor, targeted against BCR/ABL oncoprotein in mice bearing BCR/ABL-transfected cells. Leuk Res. 1994 Nov;18(11):867-73.
7 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
8 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
9 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
10 Novel dual Src/Abl inhibitors for hematologic and solid malignancies.Expert Opin Investig Drugs.2010 Aug;19(8):931-45.
11 Clinical pipeline report, company report or official report of Turning Point Therapeutics.