Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLAOHX)

Drug Name
Avdoralimab Drug Info
Synonyms IPH5401
Indication
Disease Entry ICD 11 Status REF
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2 [1]
Therapeutic Class
Antiviral Agents
Cross-matching ID
TTD Drug ID
DMLAOHX

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
HUMAN C5a receptor (C5aR) TTQLO2H C5AR1_HUMAN Inhibitor [2]

References

1 ClinicalTrials.gov (NCT04371367) Avdoralimab an Anti-C5aR Antibody, in Patients With COVID-19 Severe Pneumonia ( FORCE ). U.S. National Institutes of Health.
2 Blockade of the C5a-C5aR axis alleviates lung damage in hDPP4-transgenic mice infected with MERS-CoV. Emerg Microbes Infect. 2018 Apr 24;7(1):77.