Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLASOF)

Drug Name

GSK2606414 Drug Info

Synonyms

GSK PERK Inhibitor; 3-fluoro-GSK2606414; compound 38 [PMID: 22827572]

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting PRKR-like endoplasmic reticulum kinase (PERK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
HC-5404	DMKFZW5	Breast cancer	2C60-2C65	Phase 1	[2]
Tricyclic isoxazoloquinazoline derivative 2	DMH4TY1	N. A.	N. A.	Patented	[3]
Tricyclic isoxazoloquinazoline derivative 4	DM8VIM4	N. A.	N. A.	Patented	[3]
Tricyclic isoxazoloquinazoline derivative 3	DML2PWF	N. A.	N. A.	Patented	[3]
Phenylpyrrolidinone derivative 3	DMPZKQN	N. A.	N. A.	Patented	[3]
Indoline derivative 6	DMU5KWC	N. A.	N. A.	Patented	[3]
Tricyclic isoxazoloquinazoline derivative 1	DM6QSND	N. A.	N. A.	Patented	[3]
Phenylpyrrolidinone derivative 1	DMPAI5C	N. A.	N. A.	Patented	[3]
Phenylpyrrolidinone derivative 5	DMZSTLH	N. A.	N. A.	Patented	[3]
Indoline derivative 3	DM20YBJ	N. A.	N. A.	Patented	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Myosin light chain kinase 2 (MYLK2)	TTHLGB2	MYLK2_HUMAN	Inhibitor	[1]
PRKR-like endoplasmic reticulum kinase (PERK)	TT5OU0D	E2AK3_HUMAN	Inhibitor	[1]

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References

1	Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK). J Med Chem. 2012 Aug 23;55(16):7193-207.
2	Clinical pipeline report, company report or official report of HiberCell
3	Protein kinase R(PKR)-like endoplasmic reticulum kinase (PERK) inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Jan;27(1):37-48.