Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLEKUY)

Drug Name

APG-1387 Drug Info

Synonyms

AKLBERUGKZNEJY-RTEPGWBGSA-N; SCHEMBL15490706

Indication

Disease Entry	ICD 11	Status	REF
Haematological malignancy	2B33.Y	Phase 1	[1]
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]
Nasopharyngeal carcinoma	2B6B	Investigative	[2]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting X-linked inhibitor of apoptosis protein (XIAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AT-406	DMVJW0S	Squamous head and neck cell carcinom	2D60.0	Phase 3	[3]
Birinapant	DM6PBUM	Lymphoma	2A80-2A86	Phase 2	[4]
Phenoxodiol	DMBUJVX	Ovarian cancer	2C73	Phase 1/2	[5]
HGS-1029	DMS9WXG	Haematological malignancy	2B33.Y	Phase 1	[6]
GDC-0152	DM1B3UM	Obesity	5B81	Phase 1	[7]
PMID25980951-Compound-6	DMVSW5N	N. A.	N. A.	Patented	[8]
PMID25980951-Compound-27	DMXAH9F	N. A.	N. A.	Patented	[8]
PMID25980951-Compound-43	DMTJRCS	N. A.	N. A.	Patented	[8]
PMID25980951-Compound-1	DMYPT2H	N. A.	N. A.	Patented	[8]
PMID25980951-Compound-44	DMS5896	N. A.	N. A.	Patented	[8]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Targeting Inhibitor of apoptosis protein (hIAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AT-406	DMVJW0S	Squamous head and neck cell carcinom	2D60.0	Phase 3	[9]
LCL161	DMTM4QA	Multiple myeloma	2A83	Phase 2	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Inhibitor of apoptosis protein (hIAP)	TTS74QB	XIAP_HUMAN; BIRC2_HUMAN; BIRC3_HUMAN; BIRC1_HUMAN; BIRC7_HUMAN; BIRC5_HUMAN	Inhibitor	[1]
X-linked inhibitor of apoptosis protein (XIAP)	TTR7B60	XIAP_HUMAN	Antagonist	[2]

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	XIAP Limits Autophagic Degradation of Sox2 and Is A Therapeutic Target in Nasopharyngeal Carcinoma Stem Cells.Theranostics. 2018 Feb 5;8(6):1494-1510.
3	Debio 1143, an antagonist of multiple inhibitor-of-apoptosis proteins, activates apoptosis and enhances radiosensitization of non-small cell lung c... Am J Cancer Res. 2014 Nov 19;4(6):943-51.
4	cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner. Blood. 2014 Apr 17;123(16):2562-72.
5	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
6	Clinical pipeline report, company report or official report of Aegera Therapeutics Inc.
7	Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152). J Med Chem. 2012 May 10;55(9):4101-13.
8	Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74.
9	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7729).
10	National Cancer Institute Drug Dictionary (drug id 670651).