Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLFI7Q)

Drug Name

GSK-2251052 Drug Info

Synonyms

ABX; AN-3365; GSK '052; Boron-based LeuRS inhibitors (Gram-negative bacterial infection), Anacor/GSK; Boron-based leucyl-tRNA synthetase inhibitors (bacterial infection), Anacor/GSK

Indication

Disease Entry	ICD 11	Status	REF
Urinary tract infection	GC08	Phase 2	[1]

Cross-matching ID

PubChem CID: 46836890
CAS Number: CAS 1093643-37-8
TTD Drug ID: DMLFI7Q

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Staphylococcus Leucyl-tRNA synthetase (Stap-coc leuS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tavaborole	DM3ED1A	Onychomycosis	EE12.1	Approved	[3]
AN-2718	DM8B2WQ	Fungal infection	1F29-1F2F	Phase 1	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Staphylococcus Leucyl-tRNA synthetase (Stap-coc leuS)	TT37GL6	SYL_STAAE	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT01381549) GSK2251052 in Complicated Urinary Tract Infection. U.S. National Institutes of Health.
2	Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections. Antimicrob Agents Chemother. 2015 Jan;59(1):289-98.
3	An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site. Science. 2007 Jun 22;316(5832):1759-61.
4	Metalloid compounds as drugs. Res Pharm Sci. 2013 Jul-Sep; 8(3): 145-158.