Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLH73O)

Drug Name

PMID10602705C40 Drug Info

Synonyms

H(3)N(+)CH(CH(2)CH(2)SO(3)(-))CH(SH)CO-Ile-(3-COOH)Pro; GTPL8630

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Glutamyl aminopeptidase (ENPEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
QGC-001	DMAFUHK	Hypertension	BA00-BA04	Phase 2	[2]
KELATORPHAN	DMOX8FD	Discovery agent	N.A.	Investigative	[3]
EC33	DM67549	Discovery agent	N.A.	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutamyl aminopeptidase (ENPEP)	TT9PBIL	AMPE_HUMAN	Inhibitor	[1]

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References

1	Investigation of subsite preferences in aminopeptidase A (EC 3.4.11.7) led to the design of the first highly potent and selective inhibitors of this enzyme. J Med Chem. 1999 Dec 16;42(25):5197-211.
2	Clinical pipeline report, company report or official report of Quantum Genomics.
3	Retro-inverso concept applied to the complete inhibitors of enkephalin-degrading enzymes. J Med Chem. 1988 Sep;31(9):1825-31.
4	Aminopeptidase A, which generates one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, has a key role in central control of arterial blood pressure. Biochem Soc Trans. 2000;28(4):435-40.