Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLHPVW)

• Drug Name: L1-79 Drug Info
• Synonyms: alpha-methylparatyrosine

Indication

Disease Entry	ICD 11	Status	REF
Autism spectrum disorder	6A02	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 3125
  TTD Drug ID: DMLHPVW

Molecule-Related Drug Atlas

Drug(s) Targeting Tyrosine 3-monooxygenase (TH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Phenylalanine	DMQXI9F	Malnutrition	5B50-5B71	Approved	[3]
L-Tyrosine	DM9O8DT	Malnutrition	5B50-5B71	Approved	[4]
Tetrahydrobiopterin	DMINZ4W	Malnutrition	5B50-5B71	Approved	[5]
Metyrosine	DMBYCU0	Pheochromocytoma	5A75	Approved	[6]
ProSavin	DMJ42E6	Parkinson disease	8A00.0	Phase 1/2	[7]
OXB-102	DMXF9DM	Parkinson disease	8A00.0	Phase 1/2	[8]
7,8-dihydrobiopterin	DMQU4XM	Discovery agent	N.A.	Investigative	[9]
alpha-propyldopacetamide	DMQKMX3	Discovery agent	N.A.	Investigative	[10]
Meta-Tyrosine	DM0748C	Discovery agent	N.A.	Investigative	[9]
3-iodotyrosine	DMNZMH6	Discovery agent	N.A.	Investigative	[10]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tyrosine 3-monooxygenase (TH)	TTUHP71	TY3H_HUMAN	Inhibitor	[2]

References

• [1] ClinicalTrials.gov (NCT02947048) Safety of L1-79 in Autism. U.S. National Institutes of Health.
• [2] Effect of L1-79 on Core Symptoms of Autism Spectrum Disorder: A Case Series. Clin Ther. 2019 Oct;41(10):1972-1981.
• [3] Selectivity and affinity determinants for ligand binding to the aromatic amino acid hydroxylases. Curr Med Chem. 2007;14(4):455-67.
• [4] Effect of metals and phenylalanine on the activity of human tryptophan hydroxylase-2: comparison with that on tyrosine hydroxylase activity. Neurosci Lett. 2006 Jul 3;401(3):261-5.
• [5] Biochemistry of postmortem brains in Parkinson's disease: historical overview and future prospects. J Neural Transm Suppl. 2007;(72):113-20.
• [6] Dopamine beta-hydroxylase deficiency. A genetic disorder of cardiovascular regulation. Hypertension. 1991 Jul;18(1):1-8.
• [7] Clinical pipeline report, company report or official report of Oxford BioMedica.
• [8] Clinical pipeline report, company report or official report of Oxford BioMedica.
• [9] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [10] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1243).