Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLMUK6)

Drug Name
BIIB105 Drug Info
Synonyms ION541
Indication
Disease Entry ICD 11 Status REF
Amyotrophic lateral sclerosis 8B60.0 Phase 2 [1]
Cross-matching ID
TTD Drug ID
DMLMUK6

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Ataxin-2 messenger RNA (ATXN2 mRNA) TTPQJ7P ATX2_HUMAN Not Available [1]

References

1 ClinicalTrials.gov (NCT04494256) A Phase 1/2 Multiple-Ascending-Dose Study With a Long-Term Open-Label Extension to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Effect on Disease Progression of BIIB105 Administered Intrathecally to Adults With Amyotrophic Lateral Sclerosis With or Without Poly-CAG Expansion in the ATXN2 Gene. U.S.National Institutes of Health.