Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLPC17)

Drug Name

PMID17888661C18 Drug Info

Synonyms

GTPL3212

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Diphosphomevalonate decarboxylase (MVD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
P'-geranyl 3,5,8-trihydroxy-3-methyloctanate 8-diphosphate	DMO9BUR	Discovery agent	N.A.	Investigative	[2]
P'-geranyl 3,5,9-trihydroxy-3-methylnonanate 9-diphosphate	DM2395E	Discovery agent	N.A.	Investigative	[2]
P'-geranyl 3,5,7-trihydroxy-3-methylheptanate 7-diphosphate	DMJ4SIA	Discovery agent	N.A.	Investigative	[2]
diphosphoglycolyl proline	DM28NIU	Discovery agent	N.A.	Investigative	[3]
PMID17888661C19	DMRWTHA	Discovery agent	N.A.	Investigative	[1]
analog 3 (Vlattas et al., 1996)	DMMKGT4	Discovery agent	N.A.	Investigative	[4]
2,2-difluoromevalonate 5-diphosphate	DMKXFDA	Discovery agent	N.A.	Investigative	[1]
6-fluoromevalonate pyrophosphate	DMZ26LS	Discovery agent	N.A.	Investigative	[4]
P'-geranyl 2-fluoromevalonate 5-diphosphate	DMNY187	Discovery agent	N.A.	Investigative	[3]
2-fluoromevalonate 5-diphosphate	DMEQRHY	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Diphosphomevalonate decarboxylase (MVD)	TTE5J6X	MVD1_HUMAN	Inhibitor	[1]

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References

1	Mutation and inhibition studies of mevalonate 5-diphosphate decarboxylase. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6164-8.
2	Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase. Org Lett. 2006 Mar 16;8(6):1013-6.
3	Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure. Arch Biochem Biophys. 2008 Dec 1;480(1):58-67.
4	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 642).
5	Inhibition of mevalonate 5-diphosphate decarboxylase by fluorinated substrate analogs. Biochim Biophys Acta. 2006 Jul;1760(7):1080-7.