Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLQRFO)

Drug Name

AGN-2979 Drug Info

Synonyms

BTG-1501; SC-48274; AGN-2979 (free base); 3-[3-(Dimethylamino)propyl]-3-(3-methoxyphenyl)-4,4-dimethylpiperidine-2,6-dione; 3-[3-(Dimethylamino)propyl]-3-(3-methoxyphenyl)-4,4-dimethylpiperidine-2,6-dione monohydrochloride

Indication

Disease Entry	ICD 11	Status	REF
Psychotic disorder	6A20-6A25	Phase 2	[1]

Cross-matching ID

PubChem CID: 40914
CAS Number: CAS 53873-21-5
TTD Drug ID: DMLQRFO

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Tryptophan 5-hydroxylase 1 (TPH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
KAR5585	DMXYN1H	Pulmonary arterial hypertension	BB01.0	Phase 1	[2]
fenclonine	DMUBO3E	Discovery agent	N.A.	Investigative	[3]
alpha-propyldopacetamide	DMQKMX3	Discovery agent	N.A.	Investigative	[3]
6-fluorotryptophan	DM6YD3U	Discovery agent	N.A.	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tryptophan 5-hydroxylase 1 (TPH1)	TTZSJHV	TPH1_HUMAN	Modulator	[1]

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References

1	Antidepressant-like action of AGN 2979, a tryptophan hydroxylase activation inhibitor, in a chronic mild stress model of depression in rats. Eur Neuropsychopharmacol. 2001 Oct;11(5):351-7.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1241).
4	(+)-6-fluorotryptophan, an inhibitor of tryptophan hydroxylase: sleep and wakefulness in the rat. Neuropharmacology. 1981 Apr;20(4):335-9.