Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLTYFI)

Drug Name

NNC-26-0762 Drug Info

Synonyms

Growth hormone secretagogues, Novo Nordisk; NNC-26-0722

Indication

Disease Entry	ICD 11	Status	REF
Growth hormone deficiency	5A61.3	Terminated	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Growth hormone-releasing hormone receptor (GHRHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sermorelin	DM25HP1	Pediatric growth disorder	FB86	Approved	[3]
Tesamorelin	DM9GP85	HIV-associated lipodystrophy	1C62.1	Approved	[4]
Examorelin	DMGJMQH	Growth hormone deficiency	5A61.3	Discontinued in Phase 2	[5]
AKL-0707	DME6OXB	Lipodystrophy	EF01	Discontinued in Phase 2	[6]
L-692429	DMLHE5A	Growth hormone deficiency	5A61.3	Discontinued in Phase 1	[7]
Mutated growth hormone	DMAY50R	Acromegaly	5A60.0	Investigative	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Growth hormone-releasing hormone receptor (GHRHR)	TTG4R8V	GHRHR_HUMAN	Agonist	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010046)
2	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010046)
3	Sermorelin: a better approach to management of adult-onset growth hormone insufficiency Clin Interv Aging. 2006;1(4):307-8.
4	Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
5	Hexarelin is a stronger GH-releasing peptide than GHRH in normal cycling women but not in anorexia nervosa. J Endocrinol Invest. 1997 May;20(5):257-63.
6	A super-agonist of growth hormone-releasing hormone causes rapid improvement of nutritional status in patients with chronic kidney disease. Kidney Int. 2010 Mar;77(5):450-8.
7	Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrel... Mol Endocrinol. 2005 Sep;19(9):2400-11.
8	Treatment strategies for acromegaly. Expert Opin Emerg Drugs. 2005 Nov;10(4):875-90.