Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMM25B1)

Drug Name

BMN 250 Drug Info

Synonyms

tralesinidase alfa

Indication

Disease Entry	ICD 11	Status	REF
Mucopolysaccharidosis type IIIB	5C56.3Y	Phase 1/2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Alpha-N-acetylglucosaminidase (NAGLU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
N-Acetyl-D-glucosamine	DM1XBWR	Autoimmune diabetes	5A10	Approved	[3]
ABO-101	DMUBLC3	Mucopolysaccharidosis	5C56.3	Phase 1/2	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Alpha-N-acetylglucosaminidase (NAGLU)	TTDM6HZ	ANAG_HUMAN	Replacement	[2]

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References

1	Translational studies of intravenous and intracerebroventricular routes of administration for CNS cellular biodistribution for BMN 250, an enzyme replacement therapy for the treatment of Sanfilippo type B. Drug Deliv Transl Res. 2020 Apr;10(2):425-439.
2	Translational studies of intravenous and intracerebroventricular routes of administration for CNS cellular biodistribution for BMN 250, an enzyme replacement therapy for the treatment of Sanfilippo type B. Drug Deliv Transl Res. 2020 Apr;10(2):425-439.
3	Development of bFGF-Chitosan Matrices and Their Interactions with Human Dermal Fibroblast Cells. J Biomater Sci Polym Ed. 2009;20(10):1335-51.
4	Clinical pipeline report, company report or official report of Abeona Therapeutics.