Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMM2JXP)

Drug Name

VX-787 Drug Info

Synonyms

Pimodivir

Indication

Disease Entry	ICD 11	Status	REF
Influenza A virus infection	1E30	Phase 3	[1]

Cross-matching ID

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Influenza Polymerase basic protein 2 (Influ PB2)	TT62KQV	PB2_I34A1	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT03376321) A Study to Evaluate the Efficacy and Safety of Pimodivir in Combination With the Standard-of-Care Treatment in Adolescent, Adult, and Elderly Hospitalized Participants With Influenza A Infection. U.S. National Institutes of Health.
2	Discovery of a novel, first-in-class, orally bioavailable azaindole inhibitor (VX-787) of influenza PB2. J Med Chem. 2014 Aug 14;57(15):6668-78.