Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMM4FXA)

Drug Name

Asfotase alfa Drug Info

Synonyms

SPHEX, BioMep; SPHEX, Enobia; PHEX-based enzyme replacement therapy, BioMep; PHEX-based enzyme replacement therapy, Enobia; X-linked hypophosphatemic rickets therapy, BioMep; X-linked hypophosphatemic rickets therapy, Enobia

Indication

Disease Entry	ICD 11	Status	REF
Genetic disease	8E02	Approved	[1]

Cross-matching ID

TTD Drug ID: DMM4FXA

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Alkaline phosphatase tissue-nonspecific (ALPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[3]
DS-1211	DMY3T0L	Pseudoxanthoma elasticum	EC40	Phase 2	[4]
ALXN1850	DMSQPCT	Hypophosphatasia	5C64.3	Phase 1	[5]
ALXN1910	DMDXTAE	Discovery agent	N.A.	Phase 1	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Alkaline phosphatase tissue-nonspecific (ALPL)	TTMR5UV	PPBT_HUMAN	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT01176266) Open-Label Study of Asfotase Alfa in Infants and Children 5 Years of Age With Hypophosphatasia (HPP). U.S. National Institutes of Health.
2	Enzyme-replacement therapy in life-threatening hypophosphatasia. N Engl J Med. 2012 Mar 8;366(10):904-13.
3	Characterization of rat heart alkaline phosphatase isoenzymes and modulation of activity. Braz J Med Biol Res. 2008 Jul;41(7):600-9.
4	In Vitro and In Vivo Pharmacological Profiles of DS-1211, a Novel Potent, Selective, and Orally Bioavailable Tissue-Nonspecific Alkaline Phosphatase Inhibitor. J Bone Miner Res. 2022 Oct;37(10):2033-2043.
5	Clinical pipeline report, company report or official report of Alexion