General Information of Drug (ID: DMM52FD)

Drug Name
AEZS-126 Drug Info
Synonyms AEZS-129; AEZS-132; D-106669; D-87503; Dual PI3K/ERK kinase inhibitors, AEterna Zentaris
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Investigative [1]
Cross-matching ID
PubChem CID
25151705
TTD Drug ID
DMM52FD

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug(s) Targeting PI3-kinase gamma (PIK3CG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BAY 80-6946 DMLOS5R Follicular lymphoma 2A80 Approved [2]
IPI-145 DMWA24P Follicular lymphoma 2A80 Approved [3]
Buparlisib DM1WEHC Breast cancer 2C60-2C65 Phase 3 [4]
Enzastaurin DM5H0R9 Diffuse large B-cell lymphoma 2A81 Phase 3 [5]
Rigosertib DMOSTXF Myelodysplastic syndrome 2A37 Phase 3 [6]
GDC-0032 DMT4QHD Breast cancer 2C60-2C65 Phase 3 [5]
PQR309 DMMCYZ8 Squamous head and neck cell carcinom 2D60.0 Phase 2 [1]
SAR245409 DMQM7IL Solid tumour/cancer 2A00-2F9Z Phase 2 [7]
XL147 DMML7BE Solid tumour/cancer 2A00-2F9Z Phase 2 [7]
SF1126 DML10K3 Head and neck cancer 2D42 Phase 2 [8]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
PI3-kinase gamma (PIK3CG) TTHBTOP PK3CG_HUMAN Inhibitor [1]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2155).
2 BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110 and p110 activities in tumor cell lines and xenograft models.Mol Cancer Ther.2013 Nov;12(11):2319-30.
3 PI3K-delta and PI3K-gamma inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease models. Chem Biol. 2013 Nov 21;20(11):1364-74.
4 Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov. 2009 Aug;8(8):627-44.
5 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6 Phase I study of oral rigosertib (ON 01910.Na), a dual inhibitor of the PI3K and Plk1 pathways, in adult patients with advanced solid malignancies. Clin Cancer Res. 2014 Mar 15;20(6):1656-65.
7 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2156).
8 An integrin-targeted, pan-isoform, phosphoinositide-3 kinase inhibitor, SF1126, has activity against multiple myeloma in vivo.Cancer Chemother Pharmacol.2013 Apr;71(4):867-81.