Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMM6KZR)

Drug Name

Mutant ras vaccine Drug Info

Synonyms

Mutant ras vaccine, NCI; Ras peptide vaccine, NCI; 13 mer ras peptide, NCI

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting GTPase NRas (NRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salirasib	DMRSU4X	Lung cancer	2C25.0	Phase 2	[3]
GI-4000	DMTY4PG	Colorectal cancer	2B91.Z	Phase 2	[4]
Reovirus	DMQ73AY	Head and neck cancer	2D42	Phase 2	[5]
Perillyl alcohol	DMFWC3O	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 2	[6]
KA-10X	DM4GSHY	Solid tumour/cancer	2A00-2F9Z	Investigative	[6]
APC-300	DMNIEHV	Prostate cancer	2C82.0	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	J Clin Oncol 30, 2012 (suppl, abstr 2577).
2	The immunological and clinical effects of mutated ras peptide vaccine in combination with IL-2, GM-CSF, or both in patients with solid tumors. J Transl Med. 2014 Feb 24;12:55.
3	The Ras inhibitor farnesylthiosalicylic acid (Salirasib) disrupts the spatiotemporal localization of active Ras: a potential treatment for cancer. Methods Enzymol. 2008;439:467-89.
4	Phase II study of the GI-4000 KRAS vaccine after curative therapy in patients with stage I-III lung adenocarcinoma harboring a KRAS G12C, G12D, or G12V mutation. Clin Lung Cancer. 2014 Nov;15(6):405-10.
5	Reovirus (Reolysin) as a potential therapy for malignant peripheral nerve sheath tumors.
6	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2823).