Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMM8AY5)

Drug Name

4-(3H-indol-4-ylamino)-5-styrylnicotinonitrile Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting PKC-theta messenger RNA (PRKCQ mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PROSTRATIN	DM1HMJ5	Human immunodeficiency virus infection	1C62	Investigative	[2]
8-Octyl-benzolactam-V9	DM4Z15M	Discovery agent	N.A.	Investigative	[3]
ISIS 109351	DM508BS	Discovery agent	N.A.	Investigative	[4]
ISIS 109352	DMWK1XC	Discovery agent	N.A.	Investigative	[4]
ISIS 109353	DM6AJMC	Discovery agent	N.A.	Investigative	[4]
ISIS 109355	DMFIQGW	Discovery agent	N.A.	Investigative	[4]
4-(1H-indol-6-ylamino)-5-styrylnicotinonitrile	DMB07TU	Discovery agent	N.A.	Investigative	[1]
4-(1H-indol-5-yloxy)-5-styrylnicotinonitrile	DMH360U	Discovery agent	N.A.	Investigative	[1]
ISIS 109354	DM1REKQ	Discovery agent	N.A.	Investigative	[4]
4-(1H-indol-5-ylamino)-5-styrylnicotinonitrile	DMAU0SF	Discovery agent	N.A.	Investigative	[1]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
PKC-theta messenger RNA (PRKCQ mRNA)	TT1MS7X	KPCT_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

References

1	First generation 5-vinyl-3-pyridinecarbonitrile PKCtheta inhibitors. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5829-32.
2	A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. J Med Chem. 1992 May 29;35(11):1978-86.
3	Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta. J Med Chem. 2006 May 4;49(9):2681-8.
4	US patent application no. 6,190,869, Antisense inhibition of protein kinase C-theta expression.