Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMM9J34)

Drug Name
Benzonaphthyridine derivative 1 Drug Info
Synonyms PMID25684022-Compound-WO2008109599
Indication
Disease Entry ICD 11 Status REF
Metastatic cancer 2D50-2E2Z Patented [1]
Solid tumour/cancer 2A00-2F9Z Patented [1]
Cross-matching ID
TTD Drug ID
DMM9J34

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Pyruvate dehydrogenase kinase 1 (PDHK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dichloroacetate DMZ5Y1P Insulin-resistant disorder 5A44 Phase 4 [2]
Heteroaryl-carboxamide derivative 4 DMHUIXR Metastatic cancer 2D50-2E2Z Patented [1]
Pyrazole derivative 61 DMO6M1Q Metastatic cancer 2D50-2E2Z Patented [1]
PMID25684022-Compound-WO2011137219 37(4-6) DMSQ5J8 Metastatic cancer 2D50-2E2Z Patented [1]
Heteroaryl-carboxamide derivative 3 DMBGTNM Metastatic cancer 2D50-2E2Z Patented [1]
Pyrimidine derivative 3 DMC3E8M Metastatic cancer 2D50-2E2Z Patented [1]
Heterocyclic derivative 15 DMWZNDO Metastatic cancer 2D50-2E2Z Patented [1]
Thieno[3,2-c]pyridine-7-carboxamide derivative 2 DMOWFA5 Metastatic cancer 2D50-2E2Z Patented [1]
Heteroaryl-carboxamide derivative 9 DMI627Z Metastatic cancer 2D50-2E2Z Patented [1]
Thiazole carboxamide derivative 24 DMZ6YB0 Metastatic cancer 2D50-2E2Z Patented [1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
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Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Pyruvate dehydrogenase kinase 1 (PDHK1) TTCZOF2 PDK1_HUMAN Inhibitor [1]

References

1 PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37.
2 Comparison of Antitumor Effects of Combined and Separate Treatment with NO Synthase Inhibitor T1023 and PDK1 Inhibitor Dichloroacetate. Bull Exp Biol Med. 2019 Nov;168(1):92-94.