Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMBIHO)

• Drug Name: ONO-1301 Drug Info
• Synonyms: Ono-1301; 176391-41-6; AC1O6W2S; SCHEMBL3771841; CHEMBL188539; MFCD00936504; AKOS032954172; NCGC00165852-01; ONO-1301, > J-011185; 7,8-Dihydro-5-[(E)-[[alpha-(3-pyridyl)benzylidene]aminooxy]ethyl]-1-naphthyloxy]acetic acid; 2-[[5-[2-[(E)-[phenyl(pyridin-3-yl)methylidene]amino]oxyethyl]-7,8-dihydronaphthalen-1-yl]oxy]acetic acid; [[7,8-Dihydro-5-[2-[[[phenyl(3-pyridinyl)methylene]amino]oxy]ethyl]naphthalene-1-yl]oxy]acetic acid

Indication

Disease Entry	ICD 11	Status	REF
Angina pectoris	BA40	Preclinical	[1]

• Cross-matching ID:
  PubChem CID: 6536812
  TTD Drug ID: DMMBIHO

Molecule-Related Drug Atlas

Drug(s) Targeting Thromboxane-A synthase (TBXAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PYRIDINE	DMF8CJ9	N. A.	N. A.	Phase 4	[3]
NM-702	DMDJLY9	Angina pectoris	BA40	Phase 3	[4]
E-6700	DMUWJI4	Asthma	CA23	Phase 2	[5]
FK-070	DMJSD5W	Angina pectoris	BA40	Phase 2	[6]
EV-077	DM1FCDH	Type-2 diabetes	5A11	Phase 2	[7]
G-619	DM3H6YC	Thrombosis	DB61-GB90	Phase 1	[8]
NV-52	DM0UOA9	Inflammatory bowel disease	DD72	Phase 1	[9]
Satigrel	DM4LSJ2	Thrombosis	DB61-GB90	Discontinued in Preregistration	[10]
MILACAINIDE TARTRATE	DMJLNUD	Cardiac arrhythmias	BC9Z	Discontinued in Phase 2	[11]
Imitrodast	DMQ2ULV	Asthma	CA23	Discontinued in Phase 2	[12]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Thromboxane-A synthase (TBXAS1)	TTKNWZ4	THAS_HUMAN	Agonist	[2]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1964).
• [2] A synthetic prostacyclin agonist with thromboxane synthase inhibitory activity, ONO-1301, protects myocardium from ischemia/reperfusion injury. Eur J Pharmacol. 2012 Jan 15;674(2-3):352-8.
• [3] Highly selective inhibitors of thromboxane synthetase. 2. Pyridine derivatives. J Med Chem. 1981 Oct;24(10):1149-55.
• [4] The novel phosphodiesterase inhibitor NM-702 improves claudication-limited exercise performance in patients with peripheral arterial disease. J Am Coll Cardiol. 2006 Dec 19;48(12):2539-45.
• [5] Structure-activity relationships of (E)-3-(1,4-benzoquinonyl)-2-[(3-pyridyl)-alkyl]-2-propenoic acid derivatives that inhibit both 5-lipoxygenase and thromboxane A2 synthetase. J Med Chem. 1996 Aug 2;39(16):3148-57.
• [6] Pharmacokinetic and pharmacodynamic properties of FK070 (KDI-792), a novel thromboxane receptor antagonist/thromboxane synthetase inhibitor, after single and multiple oral administrations to healthy volunteers. J Pharm Pharmacol. 1996 Apr;48(4):380-5.
• [7] Company report (Pharmaceuticalintelligence)
• [8] G 619, a dual thromboxane synthase inhibitor and thromboxane A2 receptor antagonist, inhibits tumor necrosis factor-alpha biosynthesis. Eur J Pharmacol. 1995 Nov 3;286(1):31-9.
• [9] Phase Ib single- and multiple-dose pharmacokinetic study of oral NV-52 in healthy volunteers. Drugs R D. 2008;9(3):159-66.
• [10] Mechanisms of satigrel (E5510), a new anti-platelet drug, in inhibiting human platelet aggregation. Selectivity and potency against prostaglandin H synthases isozyme activities and phosphodiesterase isoform activities. Biol Pharm Bull. 1996 Jun;19(6):828-33.
• [11] Effects of the new class I antiarrhythmic agent Ro 22-9194, (2R)-2-amino-N-(2,6-dimethylphenyl)-N-[3-(3-pyridyl)propyl]propionamide D-tartrate, on ischemia- and reperfusion-induced arrhythmias in dogs: involvement of thromboxane A2 synthase inhibitory activity. J Pharmacol Exp Ther. 1996 Nov;279(2):877-83.
• [12] RS-5186, a novel thromboxane synthetase inhibitor with a potent and extended duration of action. Thromb Res. 1988 Sep 1;51(5):507-20.