General Information of Drug (ID: DMMFYP9)

Drug Name
ME bromodomain inhibitor Drug Info
Synonyms CHEMBL3769729; Methyl (2r)-2-[(4s)-6-(4-Chlorophenyl)-8-Methoxy-1-Methyl-4h-[1,2,4]triazolo[4,3-A][1,4]benzodiazepin-4-Yl]propanoate; ME bromodomain inhibitor; GTPL7807; SCHEMBL16771925
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
86277842
TTD Drug ID
DMMFYP9

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
OTX-015 DMI8RG1 Acute myeloid leukaemia 2A60 Phase 1/2 [2]
ABBV-744 DMTEA9C Acute myeloid leukaemia 2A60 Phase 1 [3]
PMID26924192-Compound-104 DM346EU N. A. N. A. Patented [4]
PMID26924192-Compound-102 DMEJ107 N. A. N. A. Patented [4]
PMID26924192-Compound-103 DMWOCP7 N. A. N. A. Patented [4]
PMID26924192-Compound-105 DMAWLGI N. A. N. A. Patented [4]
Pyrrolo-pyrrolone derivative 1 DMN4SE5 N. A. N. A. Patented [4]
PMID26924192-Compound-106 DM9HRZJ N. A. N. A. Patented [4]
XD14 DMUMACD Discovery agent N.A. Investigative [5]
GW841819X DMRL9IN Discovery agent N.A. Investigative [6]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bromodomain-containing protein 2 (BRD2) TTDP48B BRD2_HUMAN Inhibitor [1]

References

1 Chemical biology. A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes. Science. 2014 Oct 31;346(6209):638-41.
2 Targeting bromodomains: epigenetic readers of lysine acetylation.Nat Rev Drug Discov.2014 May;13(5):337-56.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22.
5 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading. Angew Chem Int Ed Engl. 2013 Dec 23;52(52):14055-9.
6 Discovery and characterization of small molecule inhibitors of the BET family bromodomains. J Med Chem. 2011 Jun 9;54(11):3827-38.