Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMJ635)

Drug Name

Bis(3-Fluorophenyl)-ketone]thiosemicarbazone Drug Info

Synonyms

CHEMBL602732; Bis(3-Fluorophenyl)-ketone]thiosemicarbazone

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Cathepsin L (CTSL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
KGP94	DM2NZ6K	Coagulation defect	3B10.0	Clinical trial	[2]
PMID27998201-Compound-12	DM8QZNC	Bone cancer	2B5Z	Patented	[3]
PMID27998201-Compound-5	DMVZ0ND	Chronic obstructive pulmonary disease	CA22	Patented	[3]
PMID27998201-Compound-9	DM1JOZN	Rheumatoid arthritis	FA20	Patented	[3]
PMID25399719-Compound-17	DMRXKJZ	N. A.	N. A.	Patented	[4]
PMID27998201-Compound-17	DMAZVHJ	Hair loss	ED70	Patented	[3]
Phenylalanine derivative 1	DMVYP8K	Glioma	2A00.0	Patented	[3]
PMID27998201-Compound-7	DMU4QYR	Abdominal aortic aneurysm	BD50.4	Patented	[3]
PMID27998201-Compound-6	DM0LGTY	N. A.	N. A.	Patented	[3]
PMID27998201-Compound-1	DM5QH4C	Coronavirus infection	1D92	Patented	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1415-9.
2	Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6610-5.
3	Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656.
4	An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31.