Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMKASG)

Drug Name

AGTC-0106 Drug Info

Synonyms

Alpha-1 antitrypsin deficiency gene therapy, AGTC; RAAV1-CB-hAAT; Gene therapy (alpha-1 antitrypsin deficiency), Applied Genetic Technologies

Indication

Disease Entry	ICD 11	Status	REF
Alpha-1 antitrypsin deficiency	5C5A	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Alpha-1-antitrypsin (SERPINA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glassia	DM83MOK	Emphysema	CA21	Approved	[3]
Zemaira	DMA5QPM	Emphysema	CA21	Approved	[4]
Igmesine	DMH97XA	Major depressive disorder	6A70.3	Phase 2	[5]
2-Sulfhydryl-Ethanol	DMJBO3D	Discovery agent	N.A.	Investigative	[6]
------------------------------------------------------------------------------------

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

References

1	ClinicalTrials.gov (NCT01054339) Safety & Efficacy Study of rAAV1-CB-hAAT for Alpha-1 Antitrypsin Deficiency. U.S. National Institutes of Health.
2	First gene therapy nears landmark European market authorization. Nat Biotechnol. 2012 Sep;30(9):807-9.
3	Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
4	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services.
5	Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91.
6	DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.