General Information of Drug (ID: DMMKOCL)

Drug Name
AMT-050 Drug Info
Synonyms ApoA1 deficiency gene therapy, Amsterdam Molecular Therapeutics
Indication
Disease Entry ICD 11 Status REF
Cholesterol metabolism disorder 5C8Z Terminated [1]
Cross-matching ID
TTD Drug ID
DMMKOCL

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Drug(s) Targeting Apolipoprotein A-I (APOA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
CER-001 DMWUQI9 Acute coronary syndrome BA41 Phase 2 [3]
CSL-112 DMZCG91 Arteriosclerosis BD40 Phase 2 [4]
CER-522 DMGAW0H Aortic valve stenosis BB70 Phase 1 [5]
MDCO-216 DMAQ24G Arteriosclerosis BD40 Phase 1 [6]
CRD-5 DMVU4A5 Hyperlipidaemia 5C80 Discontinued in Phase 2 [7]
APP-018 DM5L9I2 Arteriosclerosis BD40 Discontinued in Phase 1 [8]
LSI-518P DMFJPYV Cardiovascular disease BA00-BE2Z Terminated [9]
⏷ Show the Full List of 7 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Apolipoprotein A-I (APOA1) TT7GN3U APOA1_HUMAN Modulator [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026835)
2 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026835)
3 Clinical pipeline report, company report or official report of Cerenis.
4 CER-001, a HDL-mimetic, stimulates the reverse lipid transport and atherosclerosis regression in high cholesterol diet-fed LDL-receptor deficient mice. Atherosclerosis. 2014 Jan;232(1):110-8.
5 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033541)
6 MDCO-216 (Apo A-I Milano/POPC Complex) Administered to Cynomolgus Monkeys Induces Pronounced Changes in Plasma Lipids and Apolipoproteins. Circulation. 2011; 124: A10978.
7 Emerging antidyslipidemic drugs. Expert Opin Emerg Drugs. 2008 Jun;13(2):363-81.
8 Apolipoprotein A-I and its mimetics for the treatment of atherosclerosis. Curr Opin Investig Drugs. 2010 September; 11(9): 989-996.
9 Clinical review: The evolving role of HDL in the treatment of high-risk patients with cardiovascular disease. J Clin Endocrinol Metab. 2011 May;96(5):1246-57.