Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMKOCL)

• Drug Name: AMT-050 Drug Info
• Synonyms: ApoA1 deficiency gene therapy, Amsterdam Molecular Therapeutics

Indication

Disease Entry	ICD 11	Status	REF
Cholesterol metabolism disorder	5C8Z	Terminated	[1]

• Cross-matching ID: TTD Drug ID: DMMKOCL

Molecule-Related Drug Atlas

Drug(s) Targeting Apolipoprotein A-I (APOA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CER-001	DMWUQI9	Acute coronary syndrome	BA41	Phase 2	[3]
CSL-112	DMZCG91	Arteriosclerosis	BD40	Phase 2	[4]
CER-522	DMGAW0H	Aortic valve stenosis	BB70	Phase 1	[5]
MDCO-216	DMAQ24G	Arteriosclerosis	BD40	Phase 1	[6]
CRD-5	DMVU4A5	Hyperlipidaemia	5C80	Discontinued in Phase 2	[7]
APP-018	DM5L9I2	Arteriosclerosis	BD40	Discontinued in Phase 1	[8]
LSI-518P	DMFJPYV	Cardiovascular disease	BA00-BE2Z	Terminated	[9]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Apolipoprotein A-I (APOA1)	TT7GN3U	APOA1_HUMAN	Modulator	[2]

References

• [1] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026835)
• [2] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026835)
• [3] Clinical pipeline report, company report or official report of Cerenis.
• [4] CER-001, a HDL-mimetic, stimulates the reverse lipid transport and atherosclerosis regression in high cholesterol diet-fed LDL-receptor deficient mice. Atherosclerosis. 2014 Jan;232(1):110-8.
• [5] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033541)
• [6] MDCO-216 (Apo A-I Milano/POPC Complex) Administered to Cynomolgus Monkeys Induces Pronounced Changes in Plasma Lipids and Apolipoproteins. Circulation. 2011; 124: A10978.
• [7] Emerging antidyslipidemic drugs. Expert Opin Emerg Drugs. 2008 Jun;13(2):363-81.
• [8] Apolipoprotein A-I and its mimetics for the treatment of atherosclerosis. Curr Opin Investig Drugs. 2010 September; 11(9): 989-996.
• [9] Clinical review: The evolving role of HDL in the treatment of high-risk patients with cardiovascular disease. J Clin Endocrinol Metab. 2011 May;96(5):1246-57.