Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMKW8L)

Drug Name

ASTX660 Drug Info

Synonyms

YCXOHEXZVKOGEV-DNRQZRRGSA-N; 1799328-86-1; SCHEMBL16830758; CS-8216; HY-109565; 1-(6-(4-fluorobenzyl)-5-(hydroxymethyl)-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)-2-((2R,5R)-5-methyl-2-(((R)-3-methylmorpholino)methyl)piperazin-1-yl)ethan-1-one

Indication

Disease Entry	ICD 11	Status	REF
Lymphoma	2A80-2A86	Phase 2	[1]
Solid tumour/cancer	2A00-2F9Z	Phase 2	[1]

Cross-matching ID

PubChem CID: 118169620
CAS Number: CAS 1799328-86-1
TTD Drug ID: DMMKW8L

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting XIAP messenger RNA (XIAP mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AEG35156	DM2HRYD	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[2]
EMBELIN	DMFZO4Y	N. A.	N. A.	Terminated	[3]
AZD5582	DMPIHN6	Discovery agent	N.A.	Investigative	[4]
SM-337	DMOSTP9	Discovery agent	N.A.	Investigative	[5]
SM-131	DMP8VO6	Discovery agent	N.A.	Investigative	[6]
BV-6	DMDTV7A	Discovery agent	N.A.	Investigative	[7]
SM-122	DMC7YQE	Discovery agent	N.A.	Investigative	[5]
ARPFAQK-FAM	DMU70YP	Discovery agent	N.A.	Investigative	[3]
AVPIAQKSEK-FAM	DMNQ9R4	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
XIAP messenger RNA (XIAP mRNA)	TTK3WBU	XIAP_HUMAN	Inhibitor	[1]

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Teaming up to tackle RNAi delivery challenge. Nat Rev Drug Discov. 2009 Jul;8(7):525-6.
3	Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional... J Med Chem. 2004 May 6;47(10):2430-40.
4	Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582). J Med Chem. 2013 Dec 27;56(24):9897-919.
5	Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins. J Med Chem. 2010 Sep 9;53(17):6361-7.
6	Design, synthesis, and evaluation of tricyclic, conformationally constrained small-molecule mimetics of second mitochondria-derived activator of ca... J Med Chem. 2008 Dec 11;51(23):7352-5.
7	IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. Cell. 2007 Nov 16;131(4):669-81.