Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMNQE3)

Drug Name

ACH-702 Drug Info

Synonyms

ACH-702; UNII-35QF8GE1L1; 35QF8GE1L1; CHEMBL1256993; ACH702; ACH 702; SCHEMBL728226; BDBM50330327; Isothiazolo(5,4-b)quinoline-3,4(2H,9H)-dione, 7-((3R)-3-(1-amino-1-methylethyl)-1-pyrrolidinyl)-9-cyclopropyl-6-fluoro-8-methoxy-; 922491-46-1; (R)-7-[3-(1-amino-1-methyl-ethyl)-pyrrolidin-1-yl]-9-cyclopropyl-6-fluoro-8-methoxy-9H isothiazolo[5,4-b]quinoline-3,4-dione; (r)-7-(3-(2-aminopropan-2-yl)pyrrolidin-1-yl)-9-cyclopropyl-6-fluoro-8-methoxyisothiazolo[5,4-b]quinoline-3,4(2h,9h)-dione

Indication

Disease Entry	ICD 11	Status	REF
Bacterial infection	1A00-1C4Z	Investigative	[1]

Cross-matching ID

PubChem CID: 16048804
CAS Number: CAS 922491-46-1
TTD Drug ID: DMMNQE3

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Haemophilus influenzae DNA gyrase A (Hae-influ gyrA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cetraxal Otic	DMX9K3W	Otitis externa	AA00-AA13	Phase 3	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Haemophilus influenzae DNA gyrase A (Hae-influ gyrA)	TTE72ID	GYRA_HAEIN	Inhibitor	[1]

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References

1	In vitro antituberculosis activities of ACH-702, a novel isothiazoloquinolone, against quinolone-susceptible and quinolone-resistant isolates. Antimicrob Agents Chemother. 2010 Aug;54(8):3478-80.
2	DNA topoisomerases and their poisoning by anticancer and antibacterial drugs. Chem Biol. 2010 May 28;17(5):421-33.