Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMSGAT)

Drug Name

BI 207127 Drug Info

Synonyms

Deleobuvir; UNII-58BU988K90; 58BU988K90; 863884-77-9; Deleobuvir [USAN:INN]; SCHEMBL900174; SCHEMBL900176; CHEMBL2403318; DTXSID40235516; BMAIGAHXAJEULY-UKTHLTGXSA-N; SB16520; BI-207127; 1221574-24-8; (E)-3-(2-(1-(2-(5-Bromopyrimidin-2-yl)-3-cyclopentyl-1-methyl-1H-indole-6-carboxamido)cyclobutyl)-1-methyl-1H-benzo[d]imidazol-6-yl)acrylic; Deleobuvir; (E)-3-(2-(1-(2-(5-Bromopyrimidin-2-yl)-3-cyclopentyl-1-methyl-1H-indole-6-carboxamido)cyclobutyl)-1-methyl-1H-benzo[d]imidazol-6-yl)acrylic acid; 2-Propenoic acid, 3-(2-(1-(((2-(5-bromo-2-pyrimidinyl)-3-cyclopentyl-1-methyl-1H-indol-6-yl)carbonyl)amino)cyclobutyl)-1-methyl-1H-benzimidazol-6-yl)-, (2E)-; (E)-3-(2-(1

Indication

Disease Entry	ICD 11	Status	REF
Hepatitis C virus infection	1E51.1	Phase 2	[1]

Cross-matching ID

PubChem CID: 56948249
CAS Number: CAS 863884-77-9
TTD Drug ID: DMMSGAT

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PSI-7977	DMLSUWZ	HCV 1-6 infection	1E51	Approved	[2]
Setrobuvir	DMTNDM2	Hepatitis C virus infection	1E51.1	Phase 2	[3]
Valopicitabine dihydrochloride	DMFWZ2U	Virus infection	1A24-1D9Z	Phase 2	[4]
INX-189	DMSTJ6Q	Hepatitis C virus infection	1E51.1	Phase 2	[5]
Tegobuvir	DM6YI5T	Hepatitis C virus infection	1E51.1	Phase 2	[6]
VX-759	DMJUSM8	Hepatitis C virus infection	1E51.1	Phase 2	[7]
VX-135	DMZ3FE8	Hepatitis C virus infection	1E51.1	Phase 2	[8]
VX-222	DMO3U4W	Hepatitis C virus infection	1E51.1	Phase 2	[7]
BMS 791325	DMKH4PI	Hepatitis C virus infection	1E51.1	Phase 2	[9]
Filibuvir	DMNSYXB	Hepatitis C virus infection	1E51.1	Phase 2	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B)	TTMVBWH	POLG_HCV1	Inhibitor	[1]

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References

1	2011 Pipeline of Boehringer Ingelheim Pharma.
2	Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651.
3	Clinical pipeline report, company report or official report of Anadys Pharmaceuticals (2011).
4	Valopicitabine dihydrochloride:a specific polymerase inhibitor of hepatitis C virus. Curr Opin Investig Drugs. 2007 Feb;8(2):150-8.
5	Clinical pipeline report, company report or official report of Bristol-Myers Squibb.
6	Clinical pipeline report, company report or official report of Gilead (2011).
7	2011 Pipeline of Vertex.
8	All-oral HCV therapies near approval. Nat Rev Drug Discov. 2013 Jun;12(6):409-11.
9	2011 Pipeline of Bristol-Myers Squibb.
10	Clinical pipeline report, company report or official report of Pfizer (2011).