Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMUF0O)

Drug Name

AZD8630 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Asthma	CA23	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Thymic stromal lymphopoietin (TSLP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tezepelumab	DM9R5J6	Severe asthma	CA23	Approved	[3]
A378	DMUWRTB	Asthma	CA23	IND submitted	[4]
MEDI9929	DMGD1YP	Asthma	CA23	Phase 2	[5]
CSJ117	DMZJUV6	Asthma	CA23	Phase 2	[6]
AMG 104	DM3XC31	Asthma	CA23	Phase 1	[7]
PF-07275315	DMHRVUY	Atopic dermatitis	EA80	Phase 1	[8]
SAR443765	DMLYI4Z	Asthma	CA23	Phase 1	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Thymic stromal lymphopoietin (TSLP)	TTHMW3T	TSLP_HUMAN	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT05110976) Phase I, Randomised, Blinded, Placebo-controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD8630 in Healthy Adult Subjects (Part A) and Adults With Asthma on Medium to High Dose Inhaled Corticosteroids and Long-acting Beta-agonists (Part B). U.S.National Institutes of Health.
2	Clinical pipeline report, company report or official report of AstraZeneca
3	Tezepelumab in Adults with Uncontrolled Asthma. N Engl J Med. 2017 Sep 7;377(10):936-946.
4	Clinical pipeline report, company report or official report of Klus Pharma
5	Human immunoglobulin G2Lambda monoclonal antibody directed against thymic stromal lymphopoietin (MEDI9929). European medicines agency science medicines health (EMEA-001613-PIP01-14). European Union. 2015.
6	TSLP Inhibitors for Asthma: Current Status and Future Prospects. Drugs. 2020 Apr;80(5):449-458.
7	Clinical pipeline report, company report or official report of Amgen
8	Clinical pipeline report, company report or official report of Pfizer
9	Clinical pipeline report, company report or official report of Sanofi