Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMWHAV)

Drug Name

UDP-beta-S Drug Info

Synonyms

UDP-beta-S; CHEMBL2086770; SCHEMBL2705698; GTPL1750; BDBM50421169; dihydroxyphosphinothioyl [(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 22960366
TTD Drug ID: DMMWHAV

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting P2Y purinoceptor 6 (P2RY6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GC021109	DMQBEYV	Alzheimer disease	8A20	Phase 1	[3]
INS 316	DMTHMEI	Lung cancer	2C25.0	Discontinued in Phase 3	[4]
adenosine diphosphate	DMFUHKP	N. A.	N. A.	Investigative	[4]
2MeSATP	DMUE0W6	Discovery agent	N.A.	Investigative	[4]
RB 2	DMCEFUW	Discovery agent	N.A.	Investigative	[5]
PSB-0952	DMW19LB	Discovery agent	N.A.	Investigative	[5]
5BrUTP	DMEVRH4	Discovery agent	N.A.	Investigative	[4]
MRS2782	DMZSO4R	Discovery agent	N.A.	Investigative	[6]
MRS2578	DMKMPS6	Discovery agent	N.A.	Investigative	[7]
Up3U	DMKQWSB	Discovery agent	N.A.	Investigative	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
P2Y purinoceptor 6 (P2RY6)	TTNVSKA	P2RY6_HUMAN	Agonist	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1750).
2	P2 receptors activated by uracil nucleotides--an update. Curr Med Chem. 2006;13(3):289-312.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Cloning, functional expression and tissue distribution of the human P2Y6 receptor. Biochem Biophys Res Commun. 1996 May 15;222(2):303-8.
5	Development of potent and selective inhibitors of ecto-5'-nucleotidase based on an anthraquinone scaffold. J Med Chem. 2010 Mar 11;53(5):2076-86.
6	Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists. Bioorg Med Chem. 2008 Jun 15;16(12):6319-32.
7	Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors. Biochem Pharmacol. 2004 May 1;67(9):1763-70.