Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMN40DU)

Drug Name

MK-4621 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Retinoic acid-inducible gene-1 (RIG-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SB-9200	DMJRK6D	Hepatitis B virus infection	1E51.0	Phase 2	[3]
CV8102	DMYD37G	Melanoma	2C30	Phase 1	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Retinoic acid-inducible gene-1 (RIG-1)	TTVB0O3	DDX58_HUMAN	Agonist	[2]

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References

1	ClinicalTrials.gov (NCT03739138) Intratumoral/Intralesional Administration of MK-4621/JetPEI With or Without Pembrolizumab in Participants With Advanced/Metastatic or Recurrent Solid Tumors (MK-4621-002). U.S. National Institutes of Health.
2	National Cancer Institute Drug Dictionary (drug name RGT100).
3	Company reprot (Spring Bank Pharmaceuticals) (drug: SB 9200)
4	Clinical pipeline report, company report or official report of CureVac.