Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMN8AP0)

Drug Name

flufenamate Drug Info

Synonyms

Flufenamate; 2-[3-(trifluoromethyl)anilino]benzoate; 2-{[3-(trifluoromethyl)phenyl]amino}benzoate; 2-[[3-(trifluoromethyl)phenyl]amino]benzoate; 2pix; AC1MU9L1; GTPL4191; BDBM85514; CHEBI:520819; NSC_27881; ZB003097; CAS_530-78-9; CJ-00698; 2-(3-(trifluoromethyl)phenylamino)benzoate

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 3637398
ChEBI ID: CHEBI:520819
TTD Drug ID: DMN8AP0

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Polycystic kidney disease 2-like 1 (TRPP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
benzamil	DM57SVW	Discovery agent	N.A.	Investigative	[2]
citric acid	DM80YI7	Discovery agent	N.A.	Investigative	[4]
malic acid	DMU3O5H	Discovery agent	N.A.	Investigative	[4]
phenamil	DMJLUFM	Discovery agent	N.A.	Investigative	[2]
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Drug(s) Targeting Short transient receptor potential channel 6 (TRPC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-APB	DM9AKVR	Discovery agent	N.A.	Investigative	[3]
lysophosphatidylcholine	DMOGFVH	Discovery agent	N.A.	Investigative	[3]
ACAA	DMACYPW	Discovery agent	N.A.	Investigative	[3]
OAG	DMOP8IJ	Discovery agent	N.A.	Investigative	[5]
KB-R7943	DMMD5W3	Discovery agent	N.A.	Investigative	[3]
SAG	DMHOG7W	Discovery agent	N.A.	Investigative	[5]
ML9	DMP13VE	Discovery agent	N.A.	Investigative	[3]
hyp 9	DM0U8IV	Discovery agent	N.A.	Investigative	[6]
SLG	DMEBPCO	Discovery agent	N.A.	Investigative	[5]
20-HETE	DM5BAJ9	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Polycystic kidney disease 2-like 1 (TRPP2)	TTAHD89	PK2L1_HUMAN	Blocker (channel blocker)	[2]
Short transient receptor potential channel 6 (TRPC6)	TTRBT3W	TRPC6_HUMAN	Activator	[3]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4191).
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 505).
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 491).
4	Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor. Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12569-74.
5	Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature. 1999 Jan 21;397(6716):259-63.
6	Simple 2,4-diacylphloroglucinols as classic transient receptor potential-6 activators--identification of a novel pharmacophore. Mol Pharmacol. 2010 Mar;77(3):368-77.