General Information of Drug (ID: DMN8DQH)

Drug Name
Darusentan Drug Info
Synonyms Endothelin antagonist, BASF; HMR-4005; LU-127043; LU-135252
Indication
Disease Entry ICD 11 Status REF
Hypotension BA20-BA21 Phase 3 [1]
Cross-matching ID
PubChem CID
177236
CAS Number
CAS 171714-84-4
TTD Drug ID
DMN8DQH

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [3]
Ambrisentan DMD1QXW Pulmonary arterial hypertension BB01.0 Approved [4]
Macitentan DMP79A1 Cardiovascular disease BA00-BE2Z Approved [5]
Sparsentan DMMP51W IgA nephropathy MF8Y Approved [6]
LU302146 DMMJVXZ Pulmonary hypertension BB01 Approved [7]
Atrasentan DMM74PK Diabetic nephropathy GB61.Z Phase 3 [8]
Clazosentan DMQSBX4 Cerebral vasospasm BA85.Z Phase 3 [9]
PF-1228305 DMS1EQ7 Pulmonary hypertension BB01 Phase 3 [10]
BQ-123 DM0MO8I Pulmonary arterial hypertension BB01.0 Phase 2 [11]
FR139317 DMEL5SV Hypertension BA00-BA04 Phase 2 [12]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Endothelin A receptor (EDNRA) TTKRD0G EDNRA_HUMAN Antagonist [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3508).
2 Endothelin ETA receptor blockade with darusentan increases sodium and potassium excretion in aging rats. J Cardiovasc Pharmacol. 2006 Mar;47(3):456-62.
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4 Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
5 Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651.
6 Designed multiple ligands. An emerging drug discovery paradigm. J Med Chem. 2005 Oct 20;48(21):6523-43.
7 Influence of endothelin receptor antagonists on myocardial protein kinase C isoforms in uraemic cardiomyopathy. Clin Sci (Lond). 2002 Aug;103 Suppl 48:276S-279S.
8 Effects of a selective ET(A)-receptor antagonist, atrasentan (ABT-627), in murine models of allergic asthma: demonstration of mouse strain specificity. Clin Sci (Lond). 2002 Aug;103 Suppl 48:367S-370S.
9 Effects of the selective endothelin A (ET(A)) receptor antagonist Clazosentan on cerebral perfusion and cerebral oxygenation following severe subar... Acta Neurochir (Wien). 2007;149(9):911-8; discussion 918.
10 Pfizer. Product Development Pipeline. March 31 2009.
11 Endothelin in heart failure: a promising therapeutic target Heart. 1997 Feb;77(2):93-4.
12 Reduction of bFGF-induced smooth muscle cell proliferation and endothelin receptor mRNA expression by mevastatin and atorvastatin. Biochem Pharmacol. 2002 Aug 1;64(3):497-505.