Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNABMU)

Drug Name

GS-4997 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Diabetic nephropathy	GB61.Z	Phase 2	[1]
Pulmonary arterial hypertension	BB01.0	Phase 2	[2]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Apoptosis signal-regulating kinase 1 (MAP3K5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GS-4977	DMBDFN7	Diabetic nephropathy	GB61.Z	Phase 2	[3]
PMID23147077C10	DM3Z6F4	Discovery agent	N.A.	Investigative	[4]
MSC2032964A	DMS3O9H	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Apoptosis signal-regulating kinase 1 (MAP3K5)	TTOQCD8	M3K5_HUMAN	Inhibitor	[3]

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References

1	ClinicalTrials.gov (NCT02234141) GS-4997 in Adults With Pulmonary Arterial Hypertension. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Design of a phase 2 clinical trial of an ASK1 inhibitor, GS-4997, in patients with diabetic kidney disease. Nephron. 2015;129(1):29-33.
4	Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7326-9.
5	Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway. EMBO Mol Med. 2010 Dec;2(12):504-15.