Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNG84V)

Drug Name

ZK-thiazolidinone Drug Info

Synonyms

Zoledronate trisodium; Zoledronate trisodium hydrate; UNII-ARL915IH66; Zoledronate trisodium [USAN]; ARL915IH66; 165800-08-8; Zoledronate trisodium (USAN); CGP-42446B; CGP 42446B; CHEMBL3989655; D06379; Trisodium hydrogen (1-hydroxy-2-imidazol-1-ylethylidene)diphosphonate, hydrate (5:2); Phosphonic acid, (1-hydroxy-2-(1H-imidazol-1-yl)ethylidene)bis-, trisodium salt hydrate (5:2)

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Preclinical	[1]

Therapeutic Class

Anticancer Agents

Cross-matching ID

PubChem CID: 73442801
TTD Drug ID: DMNG84V

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Polo-like kinase 1 (PLK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[3]
Volasertib	DMOFH1M	Acute myeloid leukaemia	2A60	Phase 3	[4]
PCM-075	DMYFRTB	Acute myeloid leukaemia	2A60	Phase 2	[5]
BI 2536	DMJSADP	Acute myeloid leukaemia	2A60	Phase 2	[2]
MK-1496	DME1ZAH	Solid tumour/cancer	2A00-2F9Z	Phase 1	[6]
GSK461364	DM0P729	Non-hodgkin lymphoma	2B33.5	Phase 1	[2]
TAK-960	DMN4OGH	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]
CYC140	DMC6PKJ	Acute myeloid leukaemia	2A60	Phase 1	[8]
Dihydropyrido pyrazinone compound 3	DM3PEUN	N. A.	N. A.	Patented	[9]
Dihydropyrido pyrazinone compound 2	DMOTG2Y	N. A.	N. A.	Patented	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Polo-like kinase 1 (PLK1)	TTIYVQP	PLK1_HUMAN	Inhibitor	[2]

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References

1	Use of the Novel Plk1 Inhibitor ZK-Thiazolidinone to Elucidate Functions of Plk1 in Early and Late Stages of Mitosis. Mol Biol Cell. 2007 October; 18(10): 4024-4036.
2	Polo-like kinase (PLK) inhibitors in preclinical and early clinical development in oncology. Oncologist. 2009 Jun;14(6):559-70.
3	Phase I study of oral rigosertib (ON 01910.Na), a dual inhibitor of the PI3K and Plk1 pathways, in adult patients with advanced solid malignancies. Clin Cancer Res. 2014 Mar 15;20(6):1656-65.
4	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2168).
5	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6	J Clin Oncol 29: 2011 (suppl; abstr 3012).
7	TAK-960, a novel, orally available, selective inhibitor of polo-like kinase 1, shows broad-spectrum preclinical antitumor activity in multiple dosing regimens. Mol Cancer Ther. 2012 Mar;11(3):700-9.
8	Clinical pipeline report, company report or official report of Cyclacel Pharmaceuticals.
9	BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22.