Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNGQM0)

Drug Name

ARM036 Drug Info

Synonyms

ALADORIAN; UNII-PJ5KSA836G; PJ5KSA836G; 865433-00-7; ARM036; Aladorian [USAN:INN]; Aladorian (USAN/INN); S44121-1; SCHEMBL3423110; CHEMBL2104951; DTXSID40235657; FPWBHFYYVSNIFZ-UHFFFAOYSA-N; s44121; D10304; (7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)oxoacetic acid; 1,4-Benzothiazepine-4(5H)-acetic acid, 2,3-dihydro-7-methoxy-alpha-oxo-; 2-(7-Methoxy-2,3-dihydrobenzo[f][1,4]thiazepin-4(5H)-yl)-2-oxoacetic acid

Indication

Disease Entry	ICD 11	Status	REF
Heart failure	BD10-BD13	Discontinued in Phase 2	[1]

Cross-matching ID

PubChem CID: 11161474
CAS Number: CAS 865433-00-7
TTD Drug ID: DMNGQM0
VARIDT Drug ID: DR00764

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Ryanodine receptor 1 (RYR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CDP-1050	DM5BG4P	Heart failure	BD10-BD13	Discontinued in Phase 1	[2]
Benzyloxycarbonyl-glycylryanodine	DMLJMOD	Discovery agent	N.A.	Investigative	[3]
Ruthenium red	DMOHTC6	Discovery agent	N.A.	Investigative	[4]
(O10eq)-beta-alanyl-anhydro-ryanodine	DMRSZGB	Discovery agent	N.A.	Investigative	[3]
GLYCYLRYANODINE	DMTOCXZ	Discovery agent	N.A.	Investigative	[3]
N-methyl ryanodine-succinamidate	DMXGY4F	Discovery agent	N.A.	Investigative	[3]
Ryanodine	DM2K6I8	Discovery agent	N.A.	Investigative	[5]
Di-Benzyloxycarbonyl-guanidino acetylryanodine	DMAYSGI	Discovery agent	N.A.	Investigative	[3]
(O10eq)-beta-guanidinopropionylryanodine	DMSV8XM	Discovery agent	N.A.	Investigative	[3]
(O10eq)-guanidino acetylryanodine	DM97W5T	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Ryanodine receptor 1 (RYR1)	TTU5CIX	RYR1_HUMAN	Modulator	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800034371)
2	The Ryanodine Receptor Stabilizer S44121 / Arm036 Improves Peripheral and Respiratory Muscle Function in a Mouse Model of Heart Failure. Circulation. 2014; 130: A13726.
3	Amino- and guanidinoacylryanodines: basic ryanodine esters with enhanced affinity for the sarcoplasmic reticulum Ca(2+)-release channel. J Med Chem. 1993 May 14;36(10):1319-23.
4	Role of ryanodine receptor channels in Ca2+ oscillations of porcine tracheal smooth muscle. Am J Physiol. 1997 Apr;272(4 Pt 1):L659-64.
5	The contribution of inositol 1,4,5-trisphosphate and ryanodine receptors to agonist-induced Ca(2+) signaling of airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2009 Aug;297(2):L347-61.