Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNM9DZ)

Drug Name

Nepicastat oral Drug Info

Synonyms

SYN117

Indication

Disease Entry	ICD 11	Status	REF
Post-traumatic stress disorder	6B40	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Dopamine beta hydroxylase (DBH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etamicastat	DM71BZV	Heart failure	BD10-BD13	Phase 2	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine beta hydroxylase (DBH)	TTYIP79	DOPO_HUMAN	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT00641511) Pharmacogenetic Clinical Trial of Nepicastat for Post Traumatic Stress Disorder (PTSD). U.S. National Institutes of Health.
2	Catecholamine modulatory effects of nepicastat (RS-25560-197), a novel, potent and selective inhibitor of dopamine-beta-hydroxylase. Br J Pharmacol. 1997 Aug;121(8):1803-9.
3	Safety, tolerability, and pharmacokinetics of etamicastat, a novel dopamine-beta-hydroxylase inhibitor, in a rising multiple-dose study in young healthy subjects. Drugs R D. 2010;10(4):225-42.