Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNRMKA)

Drug Name
MB-3 Drug Info
Synonyms alpha-methylene-gamma-butyrolactone 3
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
91827357
TTD Drug ID
DMNRMKA

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Histone acetyltransferase KAT2B (KAT2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
garcinol DM6B9ZG Discovery agent N.A. Investigative [2]
anacardic acid DMAS5BI Discovery agent N.A. Investigative [3]
PMID15724976C1 DMBEHA5 Discovery agent N.A. Investigative [4]
LTK-14 DMW09LB Discovery agent N.A. Investigative [5]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histone acetyltransferase KAT2B (KAT2B) TTVK7SB KAT2B_HUMAN Inhibitor [1]

References

1 Design, synthesis, and biological evaluation of a small-molecule inhibitor of the histone acetyltransferase Gcn5. Angew Chem Int Ed Engl. 2004 Jul 26;43(30):3974-6.
2 Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene e... J Biol Chem. 2004 Aug 6;279(32):33716-26.
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2737).
4 Selective small molecules blocking HIV-1 Tat and coactivator PCAF association. J Am Chem Soc. 2005 Mar 2;127(8):2376-7.
5 Specific inhibition of p300-HAT alters global gene expression and represses HIV replication. Chem Biol. 2007 Jun;14(6):645-57.