General Information of Drug (ID: DMO0PS9)

Drug Name
CP-640186 Drug Info
Synonyms
CP-640186; 591778-68-6; UNII-04L1E4J3ZT; CP640186; (R)-anthracen-9-yl(3-(morpholine-4-carbonyl)-[1,4'-bipiperidin]-1'-yl)methanone; CHEMBL208943; 04L1E4J3ZT; CHEBI:45293; (3R)-1'-(9-anthrylcarbonyl)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidine; (3R)-1'-(anthracen-9-ylcarbonyl)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidine; RCP; CP 640186; {(3R)-1'-(anthracen-9-ylcarbonyl)[1,4'-bipiperidin]-3-yl}(morpholin-4-yl)methanone; [(3R)-1-[1-(anthracene-9-carbonyl)piperidin-4-yl]piperidin-3-yl]-morpholin-4-ylmethanone; 591778-70-0
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
449097
ChEBI ID
CHEBI:45293
CAS Number
CAS 591778-68-6
TTD Drug ID
DMO0PS9

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metformin DM89QE1 Colorectal carcinoma Approved [3]
PF-05175157 DMLQ3OK Type-2 diabetes 5A11 Phase 2 [4]
Axokine DMT5O8I Obesity 5B81 Discontinued in Phase 3 [5]
A-80040 DML20N9 Discovery agent N.A. Investigative [6]
AC-8632 DM09BJ4 Parkinson disease 8A00.0 Investigative [4]
QLT-091382 DMWOSFJ Sebaceous gland disease EM0Z Investigative [4]
2-[4-(2,4-Dichlorophenoxy)Phenoxy]Propanoic Acid DMWXI06 Discovery agent N.A. Investigative [7]
Soraphen A DM18IKZ Discovery agent N.A. Investigative [8]
⏷ Show the Full List of 8 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
A-80040 DML20N9 Discovery agent N.A. Investigative [6]
AC-8632 DM09BJ4 Parkinson disease 8A00.0 Investigative [9]
Haloxyfop DM5SULN Discovery agent N.A. Investigative [10]
Clodinafop DMALRU9 Discovery agent N.A. Investigative [10]
Quizalofop DM9KMEI Discovery agent N.A. Investigative [10]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Acetyl-CoA carboxylase 2 (ACACB) TTY84UG ACACB_HUMAN Inhibitor [2]
Plasmodium Acetyl-CoA carboxylase 1 (Malaria ACC1) TTYAWV0 Q9U752_PLAFA Inhibitor [1]

References

1 Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2383-8.
2 (4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6645-8.
3 AMP-activated protein kinase-dependent and -independent mechanisms underlying in vitro antiglioma action of compound C. Biochem Pharmacol. 2009 Jun 1;77(11):1684-93.
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1264).
5 Obesity: pathophysiology and clinical management. Curr Med Chem. 2009;16(4):506-21.
6 Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acet... J Med Chem. 2006 Jun 29;49(13):3770-3.
7 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
8 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
9 Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science. 2000 Jun 30;288(5475):2379-81.
10 The apicoplast as an antimalarial drug target. Drug Resist Updat. 2001 Jun;4(3):145-51.